THC-Dominant Cannabis Linked to Long-Term Relief from Anxiety and Depression

Newly published research in the Journal of Affective Disorders finds that the use of THC-dominant medical cannabis is associated with ongoing reductions in anxiety and depression symptoms.

Researchers from the Johns Hopkins University School of Medicine evaluated 33 adults with clinically significant anxiety or depression who were new to cannabis. Over a six-month period, participants used state-authorized medical cannabis products—including both botanical and edible forms—on an as-needed basis.

The study found that starting THC-dominant cannabis led to immediate improvements in anxiety and depression symptoms, with sustained relief reported over time. Participants also experienced improvements in quality of life and general health satisfaction. Importantly, cannabis use was not linked to the development of any physical or psychological problems.

“These findings offer important insights into the potential benefits of medicinal cannabis for individuals struggling with anxiety and depression,” the authors concluded. They called for further research, ideally through randomized, placebo-controlled trials, to better understand cannabis’s role as a therapeutic option.

NORML Deputy Director Paul Armentano noted that the findings align with earlier research showing consistent and statistically significant improvements in mental health outcomes among cannabis users. He also pointed out that cannabis legalization has been linked to reduced use of traditional prescription drugs like antidepressants and benzodiazepines.

Survey data consistently shows that people who use cannabis for self-medication most often do so to manage pain, anxiety, sleep issues, and depression.

The study, titled “Acute and chronic effects of medicinal cannabis use on anxiety and depression in a prospective cohort of patients new to cannabis,” is available in the Journal of Affective Disorders.